# Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy

> **NCT07443410** · NA · RECRUITING · sponsor: **University Hospital Heidelberg** · enrollment: 60 (estimated)

## Conditions studied

- Periodontitis, Adult
- Periodontitis (Stage 3)
- Periodontitis Stage IV

## Interventions

- **PROCEDURE:** Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT)
- **DIETARY_SUPPLEMENT:** Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®)
- **DIETARY_SUPPLEMENT:** Vitamin B12 drops (natural elements)

## Key facts

- **NCT ID:** NCT07443410
- **Lead sponsor:** University Hospital Heidelberg
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-10-25
- **Primary completion:** 2026-10
- **Final completion:** 2026-10
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2026-03-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07443410

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07443410, "Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT07443410. Licensed CC0.

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