# Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma

> **NCT07452458** · PHASE3 · NOT_YET_RECRUITING · sponsor: **NRG Oncology** · enrollment: 398 (estimated)

## Conditions studied

- Glioblastoma, IDH-Wildtype
- MGMT-Unmethylated Glioblastoma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Magnetic Resonance Imaging
- **OTHER:** Questionnaire Administration
- **RADIATION:** Radiation Therapy
- **DRUG:** Temozolomide
- **RADIATION:** Temporally-modulated Pulsed Radiation Therapy

## Key facts

- **NCT ID:** NCT07452458
- **Lead sponsor:** NRG Oncology
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06-08
- **Primary completion:** 2030-01-15
- **Final completion:** 2031-07-15
- **Target enrollment:** 398 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07452458

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07452458, "Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT07452458. Licensed CC0.

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