# Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study

> **NCT07454070** · NA · NOT_YET_RECRUITING · sponsor: **Jing Han** · enrollment: 120 (estimated)

## Conditions studied

- Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate)
- Acute Coronary Syndrome (ACS)
- Percutaneous Coronary Intervention (PCI)
- Depressive Disorder
- Postoperative Psychological Distress
- Heart Rate Variability (HRV)
- Inflammatory Factors
- Randomized Controlled Trial (RCT)

## Interventions

- **DEVICE:** Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Intervention
- **DEVICE:** sham Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Control

## Key facts

- **NCT ID:** NCT07454070
- **Lead sponsor:** Jing Han
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-03-08
- **Primary completion:** 2026-09-10
- **Final completion:** 2026-09-28
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-03-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07454070

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07454070, "Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT07454070. Licensed CC0.

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