Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy

NCT07456852 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

NOT_YET_RECRUITING

Status

60

Enrollment

OTHER

Sponsor class

Conditions

Malignant Digestive System Neoplasm

Interventions

PROCEDURE: Biospecimen Collection
DRUG: Capecitabine
DRUG: Diltiazem Hydrochloride
PROCEDURE: Electrocardiogram
DRUG: Fluorouracil
DEVICE: Holter Monitoring
DRUG: Isosorbide Mononitrate
OTHER: Medical Device Usage and Evaluation
DRUG: Placebo Administration
OTHER: Questionnaire Administration

Sponsor

Mayo Clinic