# Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial

> **NCT07463339** · PHASE2 · NOT_YET_RECRUITING · sponsor: **University of Calgary** · enrollment: 70 (estimated)

## Conditions studied

- Critical Illness
- Mechanical Ventilation

## Interventions

- **DRUG:** Microbiome-guided inhaled antibiotic prophylaxis
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT07463339
- **Lead sponsor:** University of Calgary
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-05-01
- **Primary completion:** 2027-04-30
- **Final completion:** 2028-04-30
- **Target enrollment:** 70 (ESTIMATED)
- **Last updated:** 2026-03-11


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07463339

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07463339, "Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial". Retrieved via AI Analytics 2026-09-09 from https://api.ai-analytics.org/clinical/NCT07463339. Licensed CC0.

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