# Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth

> **NCT07464886** · PHASE3 · RECRUITING · sponsor: **University of Cincinnati** · enrollment: 160 (estimated)

## Conditions studied

- Mild Depression

## Interventions

- **DRUG:** N-acetylcysteine
- **BEHAVIORAL:** Mindfulness-based cognitive therapy
- **DRUG:** Placebo
- **BEHAVIORAL:** Sham mindfulness-based intervention

## Key facts

- **NCT ID:** NCT07464886
- **Lead sponsor:** University of Cincinnati
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-02-26
- **Primary completion:** 2030-03
- **Final completion:** 2030-12
- **Target enrollment:** 160 (ESTIMATED)
- **Last updated:** 2026-03-11

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07464886

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07464886, "Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT07464886. Licensed CC0.

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