# A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)

> **NCT07466316** · PHASE3 · NOT_YET_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 342 (estimated)

## Conditions studied

- Rhabdomyosarcoma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Bone Scan
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **BIOLOGICAL:** Dactinomycin
- **DRUG:** Irinotecan Hydrochloride
- **PROCEDURE:** Lumbar Puncture
- **PROCEDURE:** Lymph Node Biopsy
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Positron Emission Tomography
- **RADIATION:** Radiation Therapy
- **PROCEDURE:** Resection
- **OTHER:** Survey Administration
- **DRUG:** Vincristine Sulfate
- **DRUG:** Vinorelbine Tartrate

## Key facts

- **NCT ID:** NCT07466316
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06-22
- **Primary completion:** 2031-03-31
- **Final completion:** 2031-03-31
- **Target enrollment:** 342 (ESTIMATED)
- **Last updated:** 2026-03-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07466316

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07466316, "A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT07466316. Licensed CC0.

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