Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

NCT07468136 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

NOT_YET_RECRUITING

Status

33

Enrollment

OTHER

Sponsor class

Conditions

Anaplastic Oligodendroglioma
Astrocytoma, IDH-Mutant, Grade 3
Astrocytoma, IDH-Mutant, Grade 4
Diffuse Astrocytoma
Glioblastoma, IDH-Wildtype
Malignant Glioma

Interventions

PROCEDURE: Biospecimen Collection
DRUG: Eflornithine
PROCEDURE: Lumbar Puncture
PROCEDURE: Magnetic Resonance Imaging
BIOLOGICAL: Retifanlimab
PROCEDURE: Tumor Resection

Sponsor

Mayo Clinic