Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer

NCT07472868 · clinicaltrials.gov ↗

PHASE3

Phase

NOT_YET_RECRUITING

Status

394

Enrollment

OTHER

Sponsor class

Conditions

Locally Advanced Rectal Carcinoma

Interventions

DRUG: FOLFOXIRI
DRUG: CAPOX
DRUG: FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
RADIATION: Chemoradiotherapy
PROCEDURE: Total mesorectal excision (+/- IORT)
DIAGNOSTIC_TEST: Watch-and-wait approach

Sponsor

J. W. A. Burger

Collaborators

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