# The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries

> **NCT07475156** · PHASE4 · COMPLETED · sponsor: **Ain Shams University** · enrollment: 100 (actual)

## Conditions studied

- Post Operative Delerium

## Interventions

- **DRUG:** Dexmedetomidine (DEX)
- **DRUG:** Melatonin

## Key facts

- **NCT ID:** NCT07475156
- **Lead sponsor:** Ain Shams University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2025-08-01
- **Primary completion:** 2026-01-15
- **Final completion:** 2026-02-01
- **Target enrollment:** 100 (ACTUAL)
- **Last updated:** 2026-03-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07475156

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07475156, "The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT07475156. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*