# A RCT Using Methadone in the Management of Post-Operative Pain in Total Knee Replacement

> **NCT07485803** · PHASE4 · NOT_YET_RECRUITING · sponsor: **AdventHealth** · enrollment: 192 (estimated)

## Conditions studied

- Total Knee Arthroplasty

## Interventions

- **DRUG:** Methadone

## Key facts

- **NCT ID:** NCT07485803
- **Lead sponsor:** AdventHealth
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06
- **Primary completion:** 2028-04
- **Final completion:** 2028-06
- **Target enrollment:** 192 (ESTIMATED)
- **Last updated:** 2026-03-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07485803

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07485803, "A RCT Using Methadone in the Management of Post-Operative Pain in Total Knee Replacement". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07485803. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*