# Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair

> **NCT07486167** · PHASE1,PHASE2 · NOT_YET_RECRUITING · sponsor: **Charite University, Berlin, Germany** · enrollment: 80 (estimated)

## Conditions studied

- Congenital Heart Disease
- Cardiopulmonary Bypass
- Mechanical Ventilation
- Peep Titration in Lung Protective Ventilation
- Positive End-expiratory Pressure (PEEP)
- Lung Volume
- Lung Mechanics
- Children
- Hemodynamic Changes
- Cardiac Surgery

## Interventions

- **PROCEDURE:** End-expiratory lung volume optimization maneuver with PEEP titration
- **PROCEDURE:** Standard Care (in control arm)

## Key facts

- **NCT ID:** NCT07486167
- **Lead sponsor:** Charite University, Berlin, Germany
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-09-01
- **Primary completion:** 2028-08-31
- **Final completion:** 2028-12-31
- **Target enrollment:** 80 (ESTIMATED)
- **Last updated:** 2026-04-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07486167

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07486167, "Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair". Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/clinical/NCT07486167. Licensed CC0.

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