# Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

> **NCT07490067** · PHASE4 · RECRUITING · sponsor: **University of Michigan** · enrollment: 100 (estimated)

## Conditions studied

- Heart Failure With Reduced Ejection Fraction

## Interventions

- **DRUG:** Metoprolol Succinate
- **DEVICE:** Beta-Blocker Polygenic Score
- **DEVICE:** Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)

## Key facts

- **NCT ID:** NCT07490067
- **Lead sponsor:** University of Michigan
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-04
- **Primary completion:** 2029-07
- **Final completion:** 2029-07
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2026-04-14

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07490067

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07490067, "Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT07490067. Licensed CC0.

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