# Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adults

> **NCT07491835** · NA · COMPLETED · sponsor: **Queen Mary University of London** · enrollment: 16 (actual)

## Conditions studied

- Obesity & Overweight
- Appetite Regulation

## Interventions

- **DIETARY_SUPPLEMENT:** Arm 1 (Medium Dose): 250mg DIM and 1050mg Perilla oil in GuardCap™ colon-targeted capsules, activating GPR84 and FFA4 to stimulate PYY and GLP-1 release.
- **DIETARY_SUPPLEMENT:** Arm 2 (Low Dose): 125mg DIM and 525mg Perilla oil in GuardCap™ colon-targeted capsules, activating GPR84 and FFA4 to stimulate PYY and GLP-1 release.

## Key facts

- **NCT ID:** NCT07491835
- **Lead sponsor:** Queen Mary University of London
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-10-18
- **Primary completion:** 2023-11-11
- **Final completion:** 2023-11-11
- **Target enrollment:** 16 (ACTUAL)
- **Last updated:** 2026-03-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07491835

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07491835, "Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adults". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT07491835. Licensed CC0.

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