# Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.

> **NCT07495605** · NA · NOT_YET_RECRUITING · sponsor: **Cairo University** · enrollment: 50 (estimated)

## Conditions studied

- Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp

## Interventions

- **DRUG:** 1% melatonin gel
- **DRUG:** Calcium Hydroxide (Ca(OH)2)

## Key facts

- **NCT ID:** NCT07495605
- **Lead sponsor:** Cairo University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-03-22
- **Primary completion:** 2027-12
- **Final completion:** 2027-12
- **Target enrollment:** 50 (ESTIMATED)
- **Last updated:** 2026-03-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07495605

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07495605, "Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT07495605. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*