# Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery

> **NCT07525999** · PHASE4 · NOT_YET_RECRUITING · sponsor: **Peking University First Hospital** · enrollment: 274 (estimated)

## Conditions studied

- Spinal Surgery
- Pain Intensity
- Dexmedetomidine
- Esketamine
- Postoperative Analgesia

## Interventions

- **DRUG:** Combined dexmedetomidine-esketamine administration
- **DRUG:** Placebo administration

## Key facts

- **NCT ID:** NCT07525999
- **Lead sponsor:** Peking University First Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-04
- **Primary completion:** 2027-11
- **Final completion:** 2027-12
- **Target enrollment:** 274 (ESTIMATED)
- **Last updated:** 2026-04-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07525999

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07525999, "Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT07525999. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*