# Feasibility and Expansion Trial of Transcutaneous Vagus Nerve Stimulation (tVNS) for Immune-Related Fatigue in Patients Receiving Immune Checkpoint Inhibitors

> **NCT07529431** · NA · NOT_YET_RECRUITING · sponsor: **University of Vermont Medical Center** · enrollment: 13 (estimated)

## Conditions studied

- Cancer-related Fatigue

## Interventions

- **DEVICE:** Participants will self-administer transcutaneous vagus nerve stimulation (tVNS) at home using a non-invasive auricular stimulation device for 60 minutes per day over a 6-week period. Participants will

## Key facts

- **NCT ID:** NCT07529431
- **Lead sponsor:** University of Vermont Medical Center
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-07-01
- **Primary completion:** 2030-07-01
- **Final completion:** 2035-07
- **Target enrollment:** 13 (ESTIMATED)
- **Last updated:** 2026-04-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07529431

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07529431, "Feasibility and Expansion Trial of Transcutaneous Vagus Nerve Stimulation (tVNS) for Immune-Related Fatigue in Patients Receiving Immune Checkpoint Inhibitors". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07529431. Licensed CC0.

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