# Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)

> **NCT07538479** · PHASE1 · NOT_YET_RECRUITING · sponsor: **West China Hospital** · enrollment: 24 (estimated)

## Conditions studied

- Solid Tumors
- Solid Malignancies
- Cold Exposure
- Immunotherapy

## Interventions

- **OTHER:** Controlled Cold Exposure
- **DRUG:** Investigator-Selected Standard PD-1/PD-L1 Inhibitor-Based Therapy

## Key facts

- **NCT ID:** NCT07538479
- **Lead sponsor:** West China Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-04-20
- **Primary completion:** 2027-07-31
- **Final completion:** 2029-06-30
- **Target enrollment:** 24 (ESTIMATED)
- **Last updated:** 2026-04-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07538479

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07538479, "Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT07538479. Licensed CC0.

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