# Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression

> **NCT07539805** · PHASE2 · NOT_YET_RECRUITING · sponsor: **First Affiliated Hospital of Chongqing Medical University** · enrollment: 60 (estimated)

## Conditions studied

- Major Depressive Disorder (MDD)
- Probiotic Intervention

## Interventions

- **COMBINATION_PRODUCT:** Sertraline combined with Lactobacillus crispatus
- **COMBINATION_PRODUCT:** Sertraline combined with placebo

## Key facts

- **NCT ID:** NCT07539805
- **Lead sponsor:** First Affiliated Hospital of Chongqing Medical University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-05
- **Primary completion:** 2028-02
- **Final completion:** 2028-04
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07539805

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07539805, "Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT07539805. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*