# Teen Vulnerability to Irritability: Brain and Estrogen Changes

> **NCT07544966** · PHASE4 · NOT_YET_RECRUITING · sponsor: **University of North Carolina, Chapel Hill** · enrollment: 50 (estimated)

## Conditions studied

- Depression - Major Depressive Disorder
- Irritability

## Interventions

- **DRUG:** Kurvelo
- **DRUG:** Placebo COC

## Key facts

- **NCT ID:** NCT07544966
- **Lead sponsor:** University of North Carolina, Chapel Hill
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06-01
- **Primary completion:** 2028-04
- **Final completion:** 2029-04
- **Target enrollment:** 50 (ESTIMATED)
- **Last updated:** 2026-04-22

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07544966

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07544966, "Teen Vulnerability to Irritability: Brain and Estrogen Changes". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT07544966. Licensed CC0.

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