# Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

> **NCT07544992** · PHASE1 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 24 (estimated)

## Conditions studied

- Recurrent Astrocytoma, IDH-Mutant, Grade 4
- Recurrent Glioblastoma, IDH-Wildtype

## Interventions

- **BIOLOGICAL:** Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells
- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** FDG-Positron Emission Tomography
- **PROCEDURE:** Intracranial Catheter Placement
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Resection

## Key facts

- **NCT ID:** NCT07544992
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-12-24
- **Primary completion:** 2031-11-04
- **Final completion:** 2031-11-04
- **Target enrollment:** 24 (ESTIMATED)
- **Last updated:** 2026-05-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07544992

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07544992, "Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07544992. Licensed CC0.

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