# Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery

> **NCT07557576** · NA · RECRUITING · sponsor: **Iva Smiljanić** · enrollment: 90 (estimated)

## Conditions studied

- Cleft Lip Palate
- Orofacial Cleft
- Agitation, Emergence
- Analgesia Assessment
- Analgesia
- Pediatric

## Interventions

- **DRUG:** Ketamine (1 mg/kg)
- **DRUG:** Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h)
- **DRUG:** Fentanyl 5 mcg/kg
- **DRUG:** Propofol (IV) 3-4 mg/kg
- **DRUG:** Sevoflurane (Volatile Anesthetic)
- **DRUG:** Nitrous Oxide/Oxygen
- **DRUG:** Vecuronium (0.1 mg/kg)

## Key facts

- **NCT ID:** NCT07557576
- **Lead sponsor:** Iva Smiljanić
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-05-16
- **Primary completion:** 2026-08-30
- **Final completion:** 2026-09-30
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2026-04-29

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07557576

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07557576, "Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT07557576. Licensed CC0.

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