# Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES)

> **NCT07562971** · PHASE1,PHASE2 · NOT_YET_RECRUITING · sponsor: **UMC Utrecht** · enrollment: 20 (estimated)

## Conditions studied

- Diffuse Midline Glioma, H3 K27-Altered

## Interventions

- **DEVICE:** Focused Ultrasound (FUS) Blood-Brain Barrier Opening
- **DRUG:** Temozolomide (TMZ)

## Key facts

- **NCT ID:** NCT07562971
- **Lead sponsor:** UMC Utrecht
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-05
- **Primary completion:** 2030-11
- **Final completion:** 2031-11
- **Target enrollment:** 20 (ESTIMATED)
- **Last updated:** 2026-05-01

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07562971

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07562971, "Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES)". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT07562971. Licensed CC0.

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