# Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)

> **NCT07565870** · PHASE3 · NOT_YET_RECRUITING · sponsor: **Alexandre P. Joosten** · enrollment: 400 (estimated)

## Conditions studied

- Postoperative Pain
- Recovery

## Interventions

- **DRUG:** Intravenous Methadone
- **DRUG:** Short-acting Opioids Intraoperative analgesia

## Key facts

- **NCT ID:** NCT07565870
- **Lead sponsor:** Alexandre P. Joosten
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-07-01
- **Primary completion:** 2026-12-31
- **Final completion:** 2027-03-30
- **Target enrollment:** 400 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07565870

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07565870, "Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT07565870. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*