# IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases

> **NCT07569263** · PHASE1 · NOT_YET_RECRUITING · sponsor: **University of Florida** · enrollment: 12 (estimated)

## Conditions studied

- Brain Metastases

## Interventions

- **BIOLOGICAL:** Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells

## Key facts

- **NCT ID:** NCT07569263
- **Lead sponsor:** University of Florida
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-07
- **Primary completion:** 2029-12
- **Final completion:** 2044-12
- **Target enrollment:** 12 (ESTIMATED)
- **Last updated:** 2026-05-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07569263

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07569263, "IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07569263. Licensed CC0.

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