# Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis

> **NCT07592416** · EARLY_PHASE1 · COMPLETED · sponsor: **University of Sao Paulo** · enrollment: 60 (actual)

## Conditions studied

- Healthy Adult Participants
- Periodontal Disease

## Interventions

- **DRUG:** Amoxicilin and Metronidazole
- **OTHER:** Probiotic Therapy

## Key facts

- **NCT ID:** NCT07592416
- **Lead sponsor:** University of Sao Paulo
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-08-22
- **Primary completion:** 2026-01-30
- **Final completion:** 2026-02-11
- **Target enrollment:** 60 (ACTUAL)
- **Last updated:** 2026-05-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07592416

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07592416, "Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT07592416. Licensed CC0.

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