# Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder

> **NCT07593222** · PHASE1,PHASE2 · NOT_YET_RECRUITING · sponsor: **Mclean Hospital** · enrollment: 100 (estimated)

## Conditions studied

- Major Depression
- Healthy Participants

## Interventions

- **DEVICE:** Sham iTBS
- **DEVICE:** TMS
- **DRUG:** D-cycloserine
- **DRUG:** Dextromethophan
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT07593222
- **Lead sponsor:** Mclean Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-07-01
- **Primary completion:** 2030-12-01
- **Final completion:** 2031-06-30
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2026-05-18

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07593222

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07593222, "Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder". Retrieved via AI Analytics 2026-07-19 from https://api.ai-analytics.org/clinical/NCT07593222. Licensed CC0.

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