This interim final rule amends the Department of Energy's (DOE or the Department) nuclear safety regulations to (1) establish and maintain safety bases for hazard category 1, 2, and 3 nuclear facilities and perform work in accordance with safety bases, and (2) clarify that the quality assurance work process requirements apply to standards and controls adopted to meet regulatory or contract requirements that may affect nuclear safety. The requirements in this rule apply to contractor-operated and government-operated nuclear facilities.