# Vadescana Double-Stranded RNA; Exemption From the Requirement of a Tolerance
> **Rule** · Final rule. · Published 2025-06-16 · Effective 2025-06-16 · 90 FR 25155
## Document
- **Document number:** 2025-10880
- **Category:** pesticide
- **Federal Register citation:** 90 FR 25155
- **CFR reference:** 40 CFR 180
- **Publication date:** 2025-06-16
- **Effective date:** 2025-06-16
- **EPA docket:** EPA-HQ-OPP-2023-0561
## Abstract

This regulation establishes an exemption from the requirement of a tolerance for residues of Vadescana double-stranded (ds) RNA in or on honey and honeycomb if used according to the label and good agricultural practices. GreenLight Biosciences, Inc. submitted a petition to the EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of Vadescana dsRNA (Varroa destructor-Specific Recombinant Double-Stranded Interfering Oligonucleotide EP15) under FFDCA when used in accordance with this exemption.

## Source
- [Federal Register document](https://www.federalregister.gov/documents/2025/06/16/2025-10880/vadescana-double-stranded-rna-exemption-from-the-requirement-of-a-tolerance)
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