# Skin Procurement and Engineering

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2020 · $153,924

## Abstract

The two major goals of Core B, the Skin Procurement and Engineering Core, are 1) to facilitate basic and 
translational research in skin biology through the acquisition of fresh skin and primary skin cells from normal 
and diseased humans and mice; and 2) to foster innovation in skin research through the engineering of normal 
and genetically modified human skin in vitro and in vivo. Fresh human skin and primary skin cells are highly 
valuable resources that help to extend skin research throughout the larger scientific community at our 
institution, evidenced by the large number of investigators outside the Department of Dermatology who have 
previously used our Core services and subsequently submitted new abstracts, publications, and grant 
applications on skin biology. By combining these highly utilized primary tissue services with highly innovative 
tissue engineering consultation and services, Core B aims to maximize our impact within an even broader 
scientific community. Our long-term objectives are to: (1) allow investigators both within and outside the 
Department of Dermatology to conduct research on skin biology more efficiently and effectively by centralizing 
high-volume or specialized technical services and providing the critical research infrastructure and institutional 
review board approvals for their use; (2) foster innovative exploratory projects and junior investigators in skin 
biology through our core services, with the goal of promoting new scientific collaborations, abstracts, 
manuscripts, and grants; (3) promote translational research by providing access to normal and diseased 
human skin samples that might not otherwise be available to non-physicians or have substantial administrative 
barriers to their use; and (4) integrate our core directors' research expertise into future core services to adapt 
to the emerging needs and opportunities of our membership. To accomplish these goals we will provide: (1) 
clinical and scientific expertise, administrative support, and service to procure fresh normal (adult or neonatal) 
and diseased human skin for physiologic and pathophysiologic studies; (2) scientific expertise, administrative 
support, service, and training to derive primary keratinocyte, melanocyte, and fibroblast cultures from fresh 
human and mouse skin samples; and (3) scientific expertise, administrative support, service and training to 
establish human skin xenografts derived from normal or diseased human skin, or 3-dimensional organotypic 
human skin reconstructs genetically engineered using lentivector-, shRNA-, or CRISPR/Cas9-based 
techniques.

## Key facts

- **NIH application ID:** 10000027
- **Project number:** 5P30AR069589-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Aimee S Payne
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $153,924
- **Award type:** 5
- **Project period:** 2016-09-15 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10000027

## Citation

> US National Institutes of Health, RePORTER application 10000027, Skin Procurement and Engineering (5P30AR069589-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10000027. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*