# Study Design and Data Analysis

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2020 · $203,179

## Abstract

The major goal of Resource Core C, the Study Design and Data Analysis Core, is to facilitate basic and 
translational research in cutaneous biology and disease by providing assistance to investigators on the 
planning, design, and analysis (both statistical and informatics) of studies of the skin. Core C directors will 
apply classical and innovative approaches from clinical epidemiology, biostatistics, and bioinformatics to 
enhance the efficiency, reproducibility, and validity of cutaneous research. A proper study design and statistical 
analysis plan is fundamental to providing a solid foundation for statistical inferences in both basic and clinical 
investigations. By the very nature of the services provided by Core C, the Core will be highly collaborative and 
will add value to the other cores of the SBDRC. Core C directors will encourage investigators interested in 
cutaneous research to work with Core faculty and staff at every stage of design and analysis, thus promoting a 
team science approach from hypothesis inception, to study execution, analysis, and interpretation. This level of 
collaboration will help ensure that study designs are efficient and that analyses are accurate and correct. Core 
C faculty and staff have extensive experience with the design and analysis of basic and clinical investigations 
of cutaneous biology and skin disease. Core C will provide SBDRC investigators with the following services: 
(1) Advise on appropriate study design methodologies necessary to design and implement rigorous 
experimental and clinical investigations; (2) Provide statistical analyses of investigators' experimental data to 
determine whether study results are significant; (3) Interpret research data to make scientifically and 
statistically appropriate statements; (4) Advise on appropriate translational and Phase 1 clinical trial study 
designs for translation of bench findings to human research; (5) Bioinformatics analyses of large datasets from 
Next Generation sequencing studies, including from ChIP-Seq, exome-seq, 16S RNA-seq, and phage display 
experiments. Core C will significantly add to the overall success of the SBDRC because a critical barrier to 
progress in cutaneous biology and skin disease research is the lack of integration of biostatistical, 
epidemiological, and bioinformatics approaches in basic and clinical investigations. Implementing such 
approaches from inception through project completion will improve the reproducibility and validity of research 
findings. Cores A and B will be able to leverage the expertise of Core C faculty and staff to enhance the 
efficiency, reproducibility, and validity of research promoted by the SBDRC. Core C will also develop innovative 
approaches to analyze population stratification in genetic and genomic studies and for the analysis of 
cutaneous microbiome data when existing methodologies are insufficient.

## Key facts

- **NIH application ID:** 10000028
- **Project number:** 5P30AR069589-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** David Joel Margolis
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $203,179
- **Award type:** 5
- **Project period:** 2016-09-15 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10000028

## Citation

> US National Institutes of Health, RePORTER application 10000028, Study Design and Data Analysis (5P30AR069589-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10000028. Licensed CC0.

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