# Post-Surgical Predictors of Depression and Weight Regain after Bariatric Surgery

> **NIH NIH R01** · SANFORD RESEARCH NORTH · 2020 · $673,428

## Abstract

Abstract:
 Recent studies have clearly indicated that a significant proportion of bariatric surgery patients experience
substantial weight regain and struggle with depression following their surgery. Understanding the mechanisms
that contribute to these negative clinical outcomes is of considerable scientific and clinical importance. In the
present study, we propose a model of predictors that we believe result in weight regain and depression. We
will test the idea that in the moment, stress and negative affect predict loss of control eating, and that over
time, loss of control eating predicts weight regain and depression in these patients. We will also investigate
the influence of disinhibition on these relationships. Furthermore, we will use contemporary ecological
momentary assessment and ambulatory assessment techniques to measure these variables and study their
relationship to weight regain and depression in a prospective, longitudinal design. Finally, we will longitudinally
examine weight regain and depression following bariatric surgery to clarify the temporal relationship between
these variables.

## Key facts

- **NIH application ID:** 10000130
- **Project number:** 5R01DK112487-05
- **Recipient organization:** SANFORD RESEARCH NORTH
- **Principal Investigator:** SCOTT G ENGEL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $673,428
- **Award type:** 5
- **Project period:** 2016-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10000130

## Citation

> US National Institutes of Health, RePORTER application 10000130, Post-Surgical Predictors of Depression and Weight Regain after Bariatric Surgery (5R01DK112487-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10000130. Licensed CC0.

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