# GH16-006: Conducting Public Health Research in Kenya

> **NIH ALLCDC U01** · HJF MEDICAL RESEARCH INTERNATIONAL, INC. · 2020 · $1,199,574

## Abstract

Abstract/Summary
This proposal is submitted by the HJF Medical Research International (HJFMRI) in response to
announcement RFA-GH-16-006, Conducting Public Health Research in Kenya, a funding
opportunity from the Centers for Disease Control and Prevention (CDC). The purpose of this
cooperative agreement is to conduct and monitor epidemiologic, clinical- and laboratory-based
studies of important human diseases in Kenya. In collaboration with the Kenya Medical
Research Institute (KEMRI), we are applying for Components A, B, C, D and E. For Component
A, the Division of Global Health Protection, our proposal addresses, for example: surveillance
for infectious zoonotic diseases in animals, covering causes of diseases in livestock and
quantifying the linkages between the health of people and the animals with which they live; and
the role of pathogens in acute febrile illness (AFI), characterizing the epidemiology, including
seasonality of AFI. For Component B, our proposal covers, for example, identification of clinical,
epidemiologic and nutritional characteristics of patients hospitalized with respiratory illness and
risk factors, in settings like western Kenya, which may further predispose pregnant women to
severe outcomes from influenza, especially in relationship to influenza vaccination. For
Component C, we include proposed projects, such as determination of the effectiveness of
patient delivered partner therapy in reducing Chlamydia trachomatis and Neisseria gonorrhea
re-infection in conjunction with assessment of the prevalence and incidence of human
immunodeficiency virus (HIV) infection. For Component D, for instance, we consider measuring
schistosome antigens in oral fluid samples via detection of Circulating Cathodic Antigen (CCA)
and present a sampling design to assess the therapeutic efficacy of Artemisinin-based
combination therapies for symptomatic, uncomplicated P. falciparum infection among children.
Finally, for Component E, for example, we propose a study to measure the effectiveness of
three different strategies to increase the TB case detection rate compared to the standard
approach, Directly Observed Treatment (DOTS) as implemented in Kenya. Each of our
proposed projects is consistent with and beneficial to furthering CDC Kenya's mission to
promote health through collaboration on science, policy and evidence-based public health
actions. Collaborative public health research is HJFMRI's forte, and we offer our expertise in
management to fulfill CDC strategic priorities.

## Key facts

- **NIH application ID:** 10000811
- **Project number:** 5U01GH002133-05
- **Recipient organization:** HJF MEDICAL RESEARCH INTERNATIONAL, INC.
- **Principal Investigator:** CHRISTOPHER D BAYER
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2020
- **Award amount:** $1,199,574
- **Award type:** 5
- **Project period:** 2016-09-30 → 2021-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10000811

## Citation

> US National Institutes of Health, RePORTER application 10000811, GH16-006: Conducting Public Health Research in Kenya (5U01GH002133-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10000811. Licensed CC0.

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