# Mechanisms of Translational Activation by Decapping Activators

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2020 · $306,076

## Abstract

Project Summary/Abstract
 Translation is essential for all biological processes including development, differentiation,
growth, cell fitness and cellular adaptive responses to the external environment. Consequently,
regulatory dysfunction in translation is associated with various human diseases such as
metabolic disorders, neuronal degenerative diseases and cancer. Our long-term goal is to
elucidate molecular mechanisms of translation and translational control in gene expression, and
to understand how errors in this process are related to human disease. Towards this goal, the
overall objective of the proposed research is to elucidate molecular mechanisms and
interactions that enable RNA-binding protein Sbp1 to remodel and activate the 5' untranslated
regions (5'UTRs) of mRNAs encoding eukaryotic initiation factor 4G (eIF4G). Four independent
but complementary aims are proposed. Aim 1 pursues a molecular understanding of how Sbp1
influences the formation of intermediates in translation initiation of the eIF4G mRNAs. Aim 2
and 3 seek to understand the functions of individual domains of the Sbp1 in modulating protein-
protein and protein-RNA interactions. Aim 4 is designed to reveal molecular architectures of
several functional 5'UTR-protein complexes in translation initiation. These aims will be
accomplished by using biochemical methods.

## Key facts

- **NIH application ID:** 10000937
- **Project number:** 5R01GM120552-05
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **Principal Investigator:** Hong Jin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $306,076
- **Award type:** 5
- **Project period:** 2016-09-22 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10000937

## Citation

> US National Institutes of Health, RePORTER application 10000937, Mechanisms of Translational Activation by Decapping Activators (5R01GM120552-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10000937. Licensed CC0.

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