# Role of Haptoglobin Genotype on Neuroinflammation and Coagulation Following Aneurysmal Subarachnoid Hemorrhage

> **NIH NIH K23** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2020 · $174,954

## Abstract

Project Summary
 Aneurysmal subarachnoid hemorrhage (aSAH) affects 30,000 people per year in the US and causes
significant morbidity and mortality. Following this devastating event, patients are susceptible to secondary
complications such as cerebral vasospasm and microthrombosis. Current treatments for these secondary
mechanisms of brain injury are extremely limited, leaving patients exposed to cerebral ischemia and stroke.
Due to the functional impairments caused by aSAH-induced ischemia, therapeutic clinical research remains
active but has made little progress in the last 3 decades. The purpose of this research proposal is to determine
the role of Haptoglobin (Hp) genotype to predict clinical outcome after aSAH. To support this project, several
previous studies have demonstrated a link between Hp 2-2 genotype, increased incidence of vasospasm, and
worse clinical outcome. In Aim 1, we will prospectively enroll patients, determine Hp genotype, and correlate
this with clinical data including 3-month outcome to validate Hp as a genetic predictor for poor outcome. As a
novel investigation, we will assess the inflammatory response as a function of Hp genotype. In Aim 2,
coagulation markers will be assessed in patients using collected blood samples under the premise that platelet
activation and hypercoagulability are a mechanism that mediates poor outcome. The goal of Aim 2 is to
determine which pathway of coagulation is the best target for future pharmaceutical trials. This project will
include training for Dr. Blackburn to further his development as a clinician scientist through a rigorous
curriculum developed in the Center for Clinical and Translational Sciences, dedicated statistical training, and
focused mentorship with experts in clinical trial, translational, and basic research. The project will be performed
at the UTHealth Science Center – Memorial Hermann.

## Key facts

- **NIH application ID:** 10001034
- **Project number:** 5K23NS106054-03
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **Principal Investigator:** Spiros Blackburn
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $174,954
- **Award type:** 5
- **Project period:** 2018-09-15 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001034

## Citation

> US National Institutes of Health, RePORTER application 10001034, Role of Haptoglobin Genotype on Neuroinflammation and Coagulation Following Aneurysmal Subarachnoid Hemorrhage (5K23NS106054-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10001034. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*