# Advancing Science for the Diagnosis and Treatment of Gastroparesis

> **NIH NIH U01** · JOHNS HOPKINS UNIVERSITY · 2020 · $288,253

## Abstract

Summary
Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying,
frequently associated with chronic nausea and vomiting, early satiety, postprandial
fullness, abdominal pain, and malnutrition that may require nutritional support. The
broad objectives of this proposal is to improve our understanding of this disorder and
advancing the diagnosis and treatment of gastroparesis and related disorders. We
propose to do this through three specific aims, as follows:
Specific Aim 1: To maintain, expand, and refine the Gastroparesis Registry in order to
enable critical additional and new analyses of the clinical data and biosamples.
Specific Aim 2: To conduct a randomized controlled trial of aprepitant in patients with
gastroparesis and functional dyspepsia-postprandial distress syndrome.
Specific Aim 3: To conduct a pilot and feasibility trial of a potential disease modifying
approach using pioglitazone in patients with gastroparesis

## Key facts

- **NIH application ID:** 10001062
- **Project number:** 5U01DK073983-15
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** PANKAJ J PASRICHA
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $288,253
- **Award type:** 5
- **Project period:** 2006-04-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001062

## Citation

> US National Institutes of Health, RePORTER application 10001062, Advancing Science for the Diagnosis and Treatment of Gastroparesis (5U01DK073983-15). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10001062. Licensed CC0.

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