# Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target

> **NIH NIH SC3** · JACKSON STATE UNIVERSITY · 2020 · $113,250

## Abstract

Project Summary
Neglected and emerging tropical diseases caused by eukaryotic pathogens impact hundreds of
millions of the world's population. These diseases are largely endemic to Asia, the Middle East,
Africa, South and Central America, yet they pose a significant threat to global public health,
including that of the United States. Hence, continued effort to control, eliminate, and provide safe
and effective treatment options is crucial. In this SC3 project, our efforts will be devoted to the
optimization, identification, and validation of new chemical entities as potential pre-clinical drug
candidates for malaria, caused by Plasmodium falciparum, and Human African trypanosomiasis
(HAT), caused by T. brucei gambiense/rhodesiense. We have identified a series of chemical
entities that will serve as templates for further discovery and development. In this project, we will
employ a combination of structure-, and natural products–based drug discovery approaches. In
addition, we will structurally characterize the molecular interactions between the cysteine
protease-drug target from T. brucei and its inhibitors. The successful execution of the aims and
objectives for this project will add to the knowledge of structural chemotypes important for
antitrypanosomal and antimalarial drug discovery, and it will add to the drug development
pipeline for HAT and Leishmaniasis.

## Key facts

- **NIH application ID:** 10001069
- **Project number:** 5SC3GM122629-04
- **Recipient organization:** JACKSON STATE UNIVERSITY
- **Principal Investigator:** Ifedayo Victor Ogungbe
- **Activity code:** SC3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $113,250
- **Award type:** 5
- **Project period:** 2017-09-15 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001069

## Citation

> US National Institutes of Health, RePORTER application 10001069, Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target (5SC3GM122629-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10001069. Licensed CC0.

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