DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Award will support me in establishing an independent research career using neuroimaging to investigate the role of individual differences in alcohol use disorder risk and treatment outcomes. The training component of this application builds on my neuroscience and neuroimaging background, which demonstrates a strong technical aptitude and provides a robust basic scientific foundation from which to study the psychopathology of substance risk. To achieve full research independence, I have identified four key training objectives: 1) obtain experience in a clinical setting in order to understand all aspects of alcohol use disorders and their treatment; 2 gain expertise in the area of sex differences and addiction; 3) acquire advanced training in statistical methodologies; and 4) increase knowledge about brief interventions and motivational interviewing techniques. I will be mentored through this process by Dr. Maureen Walton, Associate Professor, Department of Psychiatry at the University of Michigan, and Dr. Mary Heitzeg, Assistant Professor, Department of Psychiatry, University of Michigan. A team of carefully selected consultants will provide additional guidance and training. The proposed K01 project will take place within the University of Michigan Addiction Research Center (UMARC), Department of Psychiatry, a multidisciplinary research center that has been funded by NIAAA, NIDA, NIMH, and a number of other external funding sources to address addiction problems, their causes, and their remediation. Eighty other substance abuse research projects are active on the University of Michigan campus, and UMARC faculty interact and collaborate with these other scientists. The University's Functional MRI Laboratory is also a collaborative, interdisciplinary facility used by a number of researchers across many departments, including Psychiatry, Psychology, Biomedical Engineering, and Radiology, just to name a few. The University of Michigan's vigorous research environment nurtures an expanding group of neuroimaging researchers, including Dr. Heitzeg, who has been the lead of the neuroimaging arm of the Michigan Longitudinal Study for 8 years and was the recipient of a NIDA Early Career Investigator Award for her work in developmental neuroimaging and addiction. The research component focuses on identifying whether there are differences between male and female collegiate binge drinkers in neural regions associated with risk for alcohol use disorders--impulse control, emotion processing, and alcohol cue reactivity--and how these regions change after a brief intervention. There is substantial behavioral evidence for disparities in risk trajectories such that females tend to score higher of measures of negative affect and males tend to score higher on measures of impulsivity. This can extend into young adulthood when binge drinking and negative consequences stemming from this type o...