# Morphology and Imaging Module

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $120,955

## Abstract

SUMMARY/ABSTRACT - MORPHOLOGY AND IMAGING MODULE
 The primary function of the Morphology and Imaging Module is to provide access to expert personnel and
equipment for microscopic studies of both fixed and live ocular tissues. Housed in a suite of rooms totaling 921
sq. ft. of dedicated space, this Module enhances the research environment by making available state-of-the-art
equipment for those investigators who use anatomical and imaging techniques, and, because of the technical
expertise provided, it enables others to add anatomical techniques into their repertoire of research tools.
Access and training are provided for instrumentation used in 1) the processing of ocular tissue for light and
confocal microscopy, immunohistochemistry, and in situ hybridization, and 2) the capturing and processing of
images of living and fixed tissue by light and confocal (conventional as well as multiphoton) microscopy.
Equipment available in this module includes two cryostats, a paraffin processing and embedding station and
paraffin microtome, a Leica laser microdissection microscope, two wide-field fluorescence microscopes (an
Olympus EX-51 microscope and a Leica DM6000 microscope), a conventional Leica TCS SP5 confocal
microscope, and a multiphoton Leica TCS SP5 confocal microscope. In addition, there is a computer
workstation dedicated to image analysis with a stand-alone version of Leica AF, MetaMorph, Imaris and other
imaging software.
 The Module is staffed by a full-time technician who provides assistance with the processing and sectioning
of tissue, the design of experiments, training in the use of light and epifluorescence microscopes and
associated imaging software, and maintenance of instruments. Also staffing the module (20% effort, paid by
the Department of Ophthalmology) is the manager of the Morphology and Image Analysis Core of the Michigan
Diabetes and Research Training Center, who provides training in the use of the Leica SP5 confocal
microscopes and Leica AF, MetaMorph, and Imaris imaging software. The Morphology and Imaging Module
was moderately or extensively utilized by 17 participating investigators during the past 5 years and 16
anticipate using the Module to a moderate or extensive degree in the next funding period.

## Key facts

- **NIH application ID:** 10001518
- **Project number:** 5P30EY007003-34
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** PHILIP J GAGE
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $120,955
- **Award type:** 5
- **Project period:** 1997-05-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001518

## Citation

> US National Institutes of Health, RePORTER application 10001518, Morphology and Imaging Module (5P30EY007003-34). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10001518. Licensed CC0.

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