# Commercialization of an Ultrasound-guided Vascular Access Device

> **NIH NIH R44** · PERCEPTIVE NAVIGATION, LLC · 2020 · $1,039,548

## Abstract

PROJECT SUMMARY
Safe and reliable access to major blood vessels and internal organs will be beneficial to patients with
cardiovascular and cardiothoracic diseases. An interventional catheter with forward-viewing ultrasound imaging
capability will be developed to enable image-guided access to blood vessels and internal organs. Phase 1 and
2 experiments demonstrate feasibility of building a high resolution, forward-viewing ultrasound array and its
ability to yield clinical quality images of ex-vivo and in-vivo tissues. This Phase 2B SBIR proposal seeks to
build on the Phase 2 results and develop a clinical production grade device. Furthermore, we will demonstrate
feasibility and safety of the device in its exemplary clinical uses in preclinical testing and in human studies. The
production grade device will meet regulatory and clinical requirements and image quality to produce accurate
and safe device guidance to target organs, particularly large blood vessels and the heart. We therefore
propose to: a) demonstrate acceptable image quality and biological safety using the go-to-market device, b)
demonstrate safety, functionality, and efficacy in vivo using the go-to-market device and, c) establish clinical
feasibility and safety profile of the go-to-market device in a human study for its exemplary uses (femoral arterial
access, pleural and pericardial access). No such device is currently available in the market and the successful
development of a clinically implementable device has immense commercial potential by its ability to contribute
significantly to the advancement and expansion of minimally invasive medical procedures.

## Key facts

- **NIH application ID:** 10001566
- **Project number:** 5R44HL093879-07
- **Recipient organization:** PERCEPTIVE NAVIGATION, LLC
- **Principal Investigator:** ELENI A. LIAPI
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,039,548
- **Award type:** 5
- **Project period:** 2011-07-15 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001566

## Citation

> US National Institutes of Health, RePORTER application 10001566, Commercialization of an Ultrasound-guided Vascular Access Device (5R44HL093879-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10001566. Licensed CC0.

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