# Core D: Pharmacokinetics/Pharmacodynamics Core

> **NIH NIH P01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $238,672

## Abstract

Abstract
The Pharmacokinetics/Pharmacodynamics Core (Core D) will provide analytic resources to
each of the Projects in this application to measure concentrations of drugs and relevant
biomarkers within various sample types. This will primarily be accomplished using a mass
spectrometric approach, with which the principal investigator has significant expertise. Methods
to detect drug and drug metabolites have already been developed for both the lead (P2176) and
backup (P2114) compounds and successfully utilized to assess the pharmacokinetics of these
drugs when applied to the airways. Similarly, methods to measure relevant biomarkers have
been developed and yield biologically plausible results in preliminary experiments.
Furthermore, the Core has the capability of adding new biomarkers as the need arises.

## Key facts

- **NIH application ID:** 10001597
- **Project number:** 5P01HL108808-09
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Charles Richard Esther
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $238,672
- **Award type:** 5
- **Project period:** 2017-09-07 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001597

## Citation

> US National Institutes of Health, RePORTER application 10001597, Core D: Pharmacokinetics/Pharmacodynamics Core (5P01HL108808-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10001597. Licensed CC0.

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