# Clinical and Translational Research Core

> **NIH NIH P30** · DARTMOUTH COLLEGE · 2020 · $303,579

## Abstract

The mission of the P30-supported DartCF Clinical and Translational Research Core (CTRC) is to increase
translational research in studies on the effects of cystic fibrosis disease and treatments on the
gastrointestinal tract and organ systems other than the lung. The CTRC supports basic science
investigators and physician-scientists by facilitating access to and analysis of clinical specimens from
patients with cystic fibrosis and comparator populations. The CTRC provides assistance with all aspects of
research with human subjects including study design and approval, implementation, and analysis. In
addition, by acting as a central clearinghouse, the CTRC works to coordinate our portfolio of clinically based
studies to minimize the burden on our patient population and clinical care team and maximize scientific
impact. Samples collected include stool, serum, urine, purified immune cells, bacterial and fungal clinical
isolates from patient samples and accompanying patient data as allowed by IRB-approved protocols. The
CTRC is able to collect patient samples as part of both longitudinal and cross-sectional studies; longitudinal
studies in which samples are paired with patient health measures are particularly important for the analysis
of the effects of the gastrointestinal microbiota on outcomes. The CTRC has developed a collection of
banked samples for rapid hypothesis testing and this resource can be particularly useful for obtaining
preliminary data for new studies. The CTRC is available to all CF researchers at Dartmouth and partner
institutions. It is central to the success of our Pilot Projects and other ongoing studies directed by
members of the Dartmouth CF research community. The CTRC has four specific aims which are: (1) to
support the design and approval of CF clinical and translational research studies, (2) to facilitate collection
of specimens and data from CF patients and control subjects, (3) to archive clinical samples for current and
future research studies, and (4) to process and analyze clinical specimens efficiently. Through these aims,
we seek support research that works towards improving our understanding of CF as a systems-wide
disease in order to develop the best possible treatments and cures.
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## Key facts

- **NIH application ID:** 10001762
- **Project number:** 2P30DK117469-03
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** DEBORAH A HOGAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $303,579
- **Award type:** 2
- **Project period:** 2018-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001762

## Citation

> US National Institutes of Health, RePORTER application 10001762, Clinical and Translational Research Core (2P30DK117469-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10001762. Licensed CC0.

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