# VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Neuroimaging Core

> **NIH VA I01** · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2020 · —

## Abstract

SUMMARY
 The Chronic Effects of Neurotrauma Consortium (CENC) has been a highly productive, coordinated,
multicenter, basic science-to-bedside, research collaboration jointly funded since 2013 by the Department of
Defense and the Veterans Administration (VA). CENC linked basic, translational, epidemiologic, and clinical
neuroscience researchers from the VA, military, academia, and private sector to effectively address the
diagnostic challenges and therapeutic ramifications of mild traumatic brain injury (mTBI) and its potential long-
term effects. Experienced and proven researchers from the CENC comprise the LIMBIC team at the level of
Consortium Leadership, Core Facilities, and Research Study Directors. This proven team of leaders,
infrastructure supporters and researchers will initiate targeted, expanded research studies that extend CENC
research findings, address all priorities (required and secondary research elements) detailed in the program
announcement, and will produce deliverables for the clinicians in the field. The Neuroimaging Core is one of
four coordinated Core efforts that support the longitudinal observational and other studies in this proposal.
These Cores (Biomarkers, Neuroimaging, Data and Biostatistics, Clinical Studies) will work in concert to
accomplish three overarching, interrelated aims:
Aim 1. Transition and expand CENC to LIMBIC -- Enroll and expand sizes of relevant cohorts of Veterans (Vs)
and Service Members (SMs); expand data points collected; collect data in accordance with established
guidelines; and identify and describe key characteristics of populations to guide rigorous studies on the nature
and degree of mTBI late effects in combat Vs/SMs over time.
Aim 2. Comorbidities & neurologic sequela -- Determine prevalence and associations of mTBI with important
comorbidities and neurologic sequela, such as dementia and neurodegenerative disease, pain, psychological
health including PTSD, and neurosensory deficits, and determine nature and degree of mTBI late effects over
time. Specific to the Neuroimaging Core, we will examine findings from conventional and more advanced
magnetic resonance imaging (MRI) to elucidate imaging-related findings most predictive of associated
outcomes, biomarkers and neurodegenerative disease or functional decline.
Aim 3. Phenotypes -- Identify characteristics (e.g., repetitive mTBI, deployment-only mTBI, frequent low level
blast or other subconconcussive head/brain impact exposure, baseline neurocognitive deficits, presence of
neurologic signs, presence of symptoms), pathophysiology, biomarkers, and subpopulations (e.g., women) that
serve as risk or protective factors for long-term outcomes such as neurodegeneration, symptom burden and
health economics. The Neuroimaging Core will assist in exploration of the utility of neuroimaging in clinical
diagnosis, prognosis, injury/disease course monitoring, individualized treatment planning and evaluation of
treatment response in Veterans and Serv...

## Key facts

- **NIH application ID:** 10001813
- **Project number:** 1I01RX003444-01
- **Recipient organization:** VA SALT LAKE CITY HEALTHCARE SYSTEM
- **Principal Investigator:** Elisabeth A Wilde
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2020
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2019-10-01 → 2025-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001813

## Citation

> US National Institutes of Health, RePORTER application 10001813, VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Neuroimaging Core (1I01RX003444-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10001813. Licensed CC0.

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