# Core D: Animal Pharmacology & Models Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $110,653

## Abstract

ABSTRACT
This newly established Core D aims to advance novel small-molecule therapies for gastrointestinal, renal,
endocrine and pulmonary manifestations of CF with the potential for translation into the clinic. To achieve this
objective, Core D carries out microsomal stability, animal pharmacology, efficacy and preliminary toxicity
studies to characterize and prioritize drug candidates that are identified in Cores A and B, and optimized in
Core C. Core D also provides essential resources and expertise to advance research on CF organ
manifestations and drug discovery that include establishing experimental animal models of CF disease, and
providing transgenic mice. The proposed functions of Core D have been carried out successfully in multiple
projects during the current award period, and formally establishing Core D will enable performance of these
functions in a more efficient and organized manner. Important areas of investigation to be facilitated by Core D
include CF constipation and related disorders (meconium ileus and distal intestinal obstruction syndrome), CF-
related enteric hyperoxaluria and nephrolithiasis, CF-related diabetes mellitus and lung infections and
inflammation. Core D will perform key animal experiments to test epithelial ion transport modulators discovered
by the CF Core Center, which has a track record of identifying novel therapeutic candidates for CF
manifestations, and generating intellectual property leading to clinical development.

## Key facts

- **NIH application ID:** 10001909
- **Project number:** 2P30DK072517-16
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Onur Cil
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $110,653
- **Award type:** 2
- **Project period:** 2005-08-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001909

## Citation

> US National Institutes of Health, RePORTER application 10001909, Core D: Animal Pharmacology & Models Core (2P30DK072517-16). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10001909. Licensed CC0.

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