# Genomics and bioinformatics analysis to understand castration-resistant prostate cancer

> **NIH NIH R50** · NORTHWESTERN UNIVERSITY · 2020 · $140,380

## Abstract

Project Summary
PCa is the leading cause of cancer-related deaths in American men. Androgen deprivation
therapies (ADT) that target and suppress androgen receptor (AR) are the mainstay treatment of
advanced prostate cancer. A majority of PCa initially responds well to ADT and is called
androgen-dependent prostate cancer (ADPC). However, nearly all PCa treated with ADT
become resistant to this treatment over a period of months or years, resulting in castration-
resistant prostate cancer (CRPC), a lethal disease. Understanding the molecular events
regulating AR transcriptional activities and driving CRPC progression is essential for the
development of novel therapeutics to eradicate CRPC. The goal of the applicant is to utilize
genomic and bioinformatics approaches to integrate big data to identify the key factors leading
to drug resistance in prostate cancer. This will entail providing bioinformatics and integrative
genomics analysis to various projects studying genetic and epigenetic regulations of AR
cistrome and AR-mediated transcriptional program in the context of CRPC. In addition, Bigger
Data will be collected either from public domains or generated internally with various
collaborators and will be analyzed through integrative genomics coupled with network modeling
to discover the driver events to castration-resistant prostate cancer.

## Key facts

- **NIH application ID:** 10001965
- **Project number:** 5R50CA211271-05
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Changsheng Zhao
- **Activity code:** R50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $140,380
- **Award type:** 5
- **Project period:** 2016-09-21 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001965

## Citation

> US National Institutes of Health, RePORTER application 10001965, Genomics and bioinformatics analysis to understand castration-resistant prostate cancer (5R50CA211271-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10001965. Licensed CC0.

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