# Cytoskeletal and Cell Cycle Regulation of Cell Migration During Development

> **NIH NIH F32** · STATE UNIVERSITY NEW YORK STONY BROOK · 2020 · $64,926

## Abstract

Project Summary/Abstract
Defects in cell cycle regulation or morphogenetic movements are associated with many pathogenic processes
and are regarded as hallmarks of cancer metastasis. Motile cells are often guided non-autonomously by
attractive and/or repulsive cues. While many of the cues that guide the various cell migration events that occur
during animal development have been identified the downstream molecular mechanisms that integrate these
cues into directed motility are poorly understood. Here, I propose to fill this knowledge gap in a comparative
context, comparing mesodermal migratory precursors in two distantly related taxa, the roundworm nematode, C.
elegans and the zebrafish, D. rerio, using high-resolution sub-cellular microscopy, genetic and genomic
approaches. This proposed research will identify how upstream guidance cues regulate cytoskeletal
rearrangements and cell cycle state to ensure proper cell migration. Previous data have shown that guidance
cues are required for proper cell migration. The specific aims of this proposal seek to (1) determine the role of
guidance cues on cytoskeletal organization and dynamics during cell migration and (2) identify how cell cycle
regulation controls cell migration. This work will uncover mechanistic information identifying new targets to inhibit
cell migration and therapeutically targeting cell migration is a key step in preventing cancer metastasis.

## Key facts

- **NIH application ID:** 10001974
- **Project number:** 5F32GM133131-02
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Rebecca C Adikes
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $64,926
- **Award type:** 5
- **Project period:** 2019-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10001974

## Citation

> US National Institutes of Health, RePORTER application 10001974, Cytoskeletal and Cell Cycle Regulation of Cell Migration During Development (5F32GM133131-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10001974. Licensed CC0.

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