# Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

> **NIH NIH R44** · KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT · 2020 · $707,649

## Abstract

Abstract
In this Phase II SBIR, Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable
wireless device that monitors left ventricular pressure and volume (P-V) in rodent studies. Transgenic models
of heart disease have been created through hypothesis-driven research on rodents that seeks to both identify
mechanistic pathways in academic research and support the development of novel compounds and
medications by large pharmaceutical companies. As a result, it has become increasingly important to
accurately and thoroughly evaluate cardiac function in the mouse and rat model. Although implanted telemetric
pressure systems have been successfully commercialized for both mice and rats, a device that also measures
real-time volume in a free-roaming rodent has been absent to date. The proposed miniature, lightweight, fully
implanted device will collect pressure and volume measurements using an admittance measurement technique
and wirelessly transmit the measured data to a nearby base station.

## Key facts

- **NIH application ID:** 10002118
- **Project number:** 5R44HL132705-03
- **Recipient organization:** KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
- **Principal Investigator:** Timothy H. Riehle
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $707,649
- **Award type:** 5
- **Project period:** 2017-05-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10002118

## Citation

> US National Institutes of Health, RePORTER application 10002118, Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle (5R44HL132705-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10002118. Licensed CC0.

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