# Joint Biology Consortium Resource-based Center

> **NIH NIH P30** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $875,996

## Abstract

PROJECT SUMMARY/ABSTRACT - Overall
Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis
in adults and children. We therefore propose the Joint Biology Consortium (JBC), a shared infrastructure
based at the Brigham and Women's Hospital, Boston Children's Hospital, and the Broad Institute to accelerate
the work of an arthritis-focused Research Community at 17 research centers in the US and abroad. Three
Cores designed around the shared needs of JBC members will enhance the efficiency of existing studies,
facilitate innovation, and foster junior investigators.
1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the
scientific potential of the JBC research network. The JBC Synergy Meeting promotes scientific interchange and
collaboration, while the JBC Web Portal facilitates communication and service delivery. The JBC Enrichment
Program, incorporating innovations from award-winning mentors, supports JBC Young Investigators via grant
aims review, a novel mentoring program, and microgrants to enable utilization of JBC core service.
2. The Human Biosamples Core provides “one stop shopping” for adult and pediatric biospecimens essential to
arthritis research. Web-based searches and targeted in-clinic recruitment will transform multiple distinct
resources at BWH and Children's into a unified pipeline for biospecimens and associated clinical and genetic
data.
3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Key
services include centralized human sample processing, CyTOF, single-cell and low-input RNA-seq, and an
innovative HoxB8 technology core for generation and CRISPR/Cas9 manipulation of pre-clinical model cells,
including neutrophils, monocytes, and osteoclasts.
Spearheaded by committed arthritis researchers Director Dr. Peter Nigrovic and Associate Director Dr.
Elizabeth Karlson, the JBC will spur innovation within an inclusive and highly collaborative network of senior
and junior investigators, leading the Joint Biology Consortium to become an engine of translational research in
adult and pediatric arthritis.

## Key facts

- **NIH application ID:** 10002177
- **Project number:** 5P30AR070253-05
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Peter A Nigrovic
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $875,996
- **Award type:** 5
- **Project period:** 2016-08-11 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10002177

## Citation

> US National Institutes of Health, RePORTER application 10002177, Joint Biology Consortium Resource-based Center (5P30AR070253-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10002177. Licensed CC0.

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