# University of Washington USDRN Clinical Center (UWCC)

> **NIH NIH U01** · UNIVERSITY OF WASHINGTON · 2020 · $647,752

## Abstract

PROJECT SUMMARY/ABSTRACT
The University of Washington Urinary Stone Disease Clinical Center (UWCC) seeks to advance the field of
urinary stone disease (USD) research through participation in the Research Network and by taking a
comprehensive aim at the problem of ureteral stent burden. In the United States, USD affects 1 in 9 adults,
exerting a substantial burden related to pain, lost work, and healthcare expenditures that add up to $10 billion
per year. The per capita disability from USD in the United States is higher than any other nation, potentially
reflecting the cost and side effects of intensive treatment. A team of investigators with broad experience in
urology, pediatrics, nephrology, health services, bioinformatics, pharmacogenetics, pain medicine, and
biostatistics across the University of Washington, Seattle Children's Hospital, and the VA Puget Sound Health
Care System will address this complex problem, harnessing the extensive patient care and research
infrastructure of these institutions. The clinical activity of 6 hospitals will be harnessed to provide the platform
for sufficient sample sizes to address two main facets of USD. Our specific aims include (1) to determine the
effectiveness of a short message service (SMS, or text) reminder-optimized, fluid-intake intervention on kidney
stone recurrence in urinary stone formers; (2) to characterize the symptom burden of ureteral stents and to
evaluate strategies that reduce ureteral stent-related pain and discomfort; and (3) to identify novel mechanistic
candidates associated with stent-related pain and urinary bother. Our interrelated aims set the stage for future
USDRN-wide trials to move top study designs and tools into translational applications, including those for
disease prevention, drug targeting of severe stent-related problems, and biomarker development. We envision
that our proposed strategies will move USD prevention and treatment beyond a trial-and-error approach,
informing clinically relevant intervention and prevention decisions at both an individual and a population level.

## Key facts

- **NIH application ID:** 10002327
- **Project number:** 5U01DK110954-05
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Jonathan D. Harper
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $647,752
- **Award type:** 5
- **Project period:** 2016-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10002327

## Citation

> US National Institutes of Health, RePORTER application 10002327, University of Washington USDRN Clinical Center (UWCC) (5U01DK110954-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10002327. Licensed CC0.

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