# Central Hub for Kidney Precision Medicine

> **NIH NIH U2C** · UNIVERSITY OF WASHINGTON · 2020 · $4,285,238

## Abstract

ABSTRACT
A major challenge for modern biomedical research has been the relative inability to translate the
increasing rate of scientific discovery into major therapeutic breakthroughs. This shortcoming has
been particularly dramatic in kidney diseases, where the number of randomized clinical trials
published in nephrology is fewer than all other specialties of internal medicine. chronic kidney
disease (CKD) is a public health problem affecting more than 20 million people in the US, few drugs
other than inhibitors of the renin-angiotensin system have been proven to slow CKD progression,
lower mortality rates, or improve quality of life. Acute kidney injury (AKI) affects up to 10% of all
hospitalized patients in the US, and is associated with mortality, prolonged hospital length of stay,
and subsequent development or progression of CKD. Currently there is no accepted therapeutic
approach to either prevention or amelioration of the course of AKI There is a critical need to help
define CKD and AKI disease subgroups and identify critical cells, pathways and targets for novel
therapies. We propose to establish a multiscale understanding of CKD and AKI, by integrating
clinical data with the cell and organ level features of kidney disease progression including
interrogation of genomic and epigenomic drivers of disease. We plan to build the Kidney Precision
Medicine Project Central Hub on strong existing infrastructure led by a highly experienced,
multidisciplinary team with a strong track record of success. The overarching objective of this
Central Hub application for the KPMP is to create an environment to promote scientific rigor, patient
safety, and the successful interdisciplinary team science necessary to result in major advances in
kidney disease research. In order to accomplish this, we have assembled a team with expertise in
data coordinating center management, programming, biostatistics, biomedical informatics, and
epidemiology, with over 25 years of experience coordinating highly successful large-scale
longitudinal research studies. Our investigative team was instrumental in establishing a global renal
research ecosystem, and has pioneered development of a team science structure to advance a
precision medicine approach to glomerular diseases. We have demonstrated our ability to 1) collect,
curate, aggregate and ensure quality control of all KPMP data and samples, 2) coordinate storage
and distribution of all KPMP data and samples, 3) facilitate data analyses and visualization, 4)
create a kidney tissue atlas, 5) provide administrative support and establish necessary working
groups, 6) solicit patient input and feedback, 7) develop and manage a website for internal and
external communication, analysis and discovery, and 8) administer an Opportunity Pool of funds to
form new partnerships.

## Key facts

- **NIH application ID:** 10002329
- **Project number:** 5U2CDK114886-04
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Jonathan Himmelfarb
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $4,285,238
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10002329

## Citation

> US National Institutes of Health, RePORTER application 10002329, Central Hub for Kidney Precision Medicine (5U2CDK114886-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10002329. Licensed CC0.

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